NH4Cl Treatment Prevents Tissue Calcification in Klotho Deficiency
نویسندگان
چکیده
منابع مشابه
Eicosapentaenoic acid prevents arterial calcification in klotho mutant mice
BACKGROUND The klotho gene was identified as an "aging-suppressor" gene that accelerates arterial calcification when disrupted. Serum and vascular klotho levels are reduced in patients with chronic kidney disease, and the reduced levels are associated with arterial calcification. Intake of eicosapentaenoic acid (EPA), an n-3 fatty acid, reduces the risk of fatal coronary artery disease. However...
متن کاملKlotho deficiency causes vascular calcification in chronic kidney disease.
Soft-tissue calcification is a prominent feature in both chronic kidney disease (CKD) and experimental Klotho deficiency, but whether Klotho deficiency is responsible for the calcification in CKD is unknown. Here, wild-type mice with CKD had very low renal, plasma, and urinary levels of Klotho. In humans, we observed a graded reduction in urinary Klotho starting at an early stage of CKD and pro...
متن کامل1,25(OH)2D3 dependent overt hyperactivity phenotype in klotho-hypomorphic mice
Klotho, a protein mainly expressed in kidney and cerebral choroid plexus, is a powerful regulator of 1,25(OH)2D3 formation. Klotho-deficient mice (kl/kl) suffer from excessive plasma 1,25(OH)2D3-, Ca(2+)- and phosphate-concentrations, leading to severe soft tissue calcification and accelerated aging. NH4Cl treatment prevents tissue calcification and premature ageing without affecting 1,25(OH)2D...
متن کاملKlotho prevents renal calcium loss.
Disturbed calcium (Ca(2+)) homeostasis, which is implicit to the aging phenotype of klotho-deficient mice, has been attributed to altered vitamin D metabolism, but alternative possibilities exist. We hypothesized that failed tubular Ca(2+) absorption is primary, which causes increased urinary Ca(2+) excretion, leading to elevated 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] and its sequelae. He...
متن کاملIs NaHCO3 an antiaging elixir?
EVOLVING EVIDENCE supports that deviation from normal toward the acid spectrum of the acid-base balance is associated with premature death compared with patients with a normal acidbase status. Patients with nondialysis-dependent chronic kidney disease (CKD) and metabolic acidosis have increased mortality compared with CKD patients without metabolic acidosis (5, 9). Furthermore, the risk for mor...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2015
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2014030230